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Stroke Magnetic Resonance Imaging Within 6 Hours After Onset of Hyperacute Cerebral Ischemia
Ann Neurol 49:460-469, Schellinger,P.D.,et al, 2001
See this aricle in Pubmed

Article Abstract
We have concluded on the basis of this study that early recanalization saves tissue at risk of ischemic infarction and results in significantly smaller infarcts and a significantly better clinical outcomes. Patients with proximal vessel occ lusions have a larger amount of tissue at risk, a lower recanalization rate, and a worse outcome. Urgent recanalization seems to be of utmost importance for these patients.
 
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